Guido Verbeck

Associate Professor
Chemistry and Biochemistry

Dr. Guido F. Verbeck, Associate Professor of Chemistry and Biochemistry, is an expert is mass spectrometry, specifically instrument design and development.  Dr. Verbeck received his PhD as a Proctor & Gamble fellow in chemistry at Texas A&M University. Dr. Verbeck has developed ion cyclotron resonance, time-of-flight, and ion trap mass spectrometers over the past 17 years, and has been a member of the analytical community for 22 years. Among this design portfolio, Dr. Verbeck has developed a miniature ion trap mass spectrometer at Oak Ridge National Laboratory, 3 preparative mass spectrometers for combing new materials and catalysts, and a number of novel analytical applications for single cell and forensic analysis. Dr. Verbeck’s appointment is currently at the University of North Texas where he continues to design novel ion optical devices for miniaturization, preparative, and analytical mass spectrometry, and he is the Director for the Laboratory of Imaging Mass Spectrometry

Research Interests: 
  • Develop the nanomanipulation platform and utilize in direct analyte probe nano-extraction within Biochemistry, Forensic Science, and Analytical Chemical applications.
  • Continue to develop micro mass spectrometry and applications, specifically for field portable instrumentation.
  • Further develop soft-landing mass spectrometry and drift tubes to comb for new materials and aid in understanding a bottom-up approach.
  • Identify new growth areas within mass spectrometry, and exploit our expertise to find future funding.
  • National Institute of Justice (NIJ-2013-3361). Golden, T., Microscopy with Direct Analyte Probe Nanoextraction (DAPNe)-Coupled to Nanospray Mass Spectrometry for Localized Chemical Analysis of Document Inks. (PI). $380,986. 1/1/14-12/31/16.
  • Inficon, Instrument Grant, Development of a Portable Quadrupole Mass Analyzer for the Analysis on In-Situ Field Measurements, Specifically Oil and Gas Wells. (PI). $150,000. 1/1/13-12/31/16.
Publications: 

Full List: Google Scholar

Hamilton, J.S. and Verbeck, G.F. (2016). One-Cell Analysis as a Technique for True Single-Cell Analysis of Organelles in Breast Tumor and Adjacent Normal Tissue to Profile Fatty Acid Composition of Triglyceride Species. J. Anal. Onocology 5 47-54.

Hamilton, J.S., Gorishek, E.L., Mach, P.M., Sturtevant, D., Ladage, M.L., Suzuki, N., Padilla, P.A., Mittler, R., Chapman, K.D. and Verbeck, G.F. (2016). Evaluation of a custom single Peltier-cooled ablation cell for elemental imaging of biological samples in laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS). J. Anal. At. Spectrom., 31 1030-1033.

Phelps, M., Sturtevant, D., Chapman, K.D. and Verbeck, G.F. (2016). Nanomanipulation-Coupled Matrix-Assisted Laser Desorption/ Ionization-Direct Organelle Mass Spectrometry: A Technique for the Detailed Analysis of Single Organelles. J. Am. Soc. Mass Spectrom 27 187-193.

Phelps, M. and Verbeck, G.F. (2015). A lipidomics demonstration of the importance of single cell analysis. Anal. Meth. 7 3668-3670.

Phelps, M., Hamilton, J. and Verbeck, G.F. (2014). Nanomanipulation-coupled nanospray mass spectrometry as an approach for single cell analysis. Rev. Sci. Inst., 85 124101.

Horn, P.J., Hoffmann, W.D., Behrendt, A.K., Chapman, K.D. and Verbeck, G.F. (2012). Liquid-Phase Microextraction and Controlled Emitter Tip Chemistry-Coupled to Nanospray Mass Spectrometry for Direct Lipid Analysis. Rapid Comm. Mass Spect. 26 957.

Clemons, K., Nnaji, C., and Verbeck, G.F. (2014). Overcoming Selectivity and Sensitivity Issues of Direct Inject Electrospray Mass Spectrometry via DAPNE-NSI-MS. J. Amer. Soc. Mass Spectrum 25 705. (invited)

Elfakhani, M., Torabi, S., Hussein, D., Mills, N. Verbeck, G.F. and Mo, H. (2014). Mevalonate deprivation mediates the impact of lovastatin on the differentiation of murine 3T3-F442A preadipocytes. Experimental Biology and Medicine 239 293-301.

Horn, P.J., Hoffmann, W.D., Behrendt, A.K., Chapman, K.D. and Verbeck, G.F. (2012). Liquid-Phase Microextraction and Controlled Emitter Tip Chemistry-Coupled to Nanospray Mass Spectrometry for Direct Lipid Analysis. Rapid Comm. Mass Spect. 26 957.

Horn, P.J., Ledbetter, N.R., James, C.N., Hoffmann, W.D., Case, C.R., Verbeck, G.F. and Chapman, K.D. (2011). Visulization of Lipid Droplet Composition by Direct Organelle Mass Spectrometry. J. Biol. Chem. 286 3298.

Patents: 
  • Nanomanipulation-Coupled to Mass Spectrometry (III). G.F. Verbeck. US patent number 09218947 B2. December 22, 2015.
  • Nanomanipulation-Coupled to Mass Spectrometry (II). G.F. Verbeck. US patent number 08829431 B2. September 9, 2014.
  • Nanomanipulation-Coupled to Mass Spectrometry (I). G.F. Verbeck. US patent number 08766177. July 1, 2014.
  • Controlled Deposition of Metal and Metal Cluster Ions by Surface Field Pattering in Soft-Landing Devices, G.F. Verbeck and S. Davila. US patent number 08651048. February 18, 2014.
  • Silver and Silver Nanoparticle MALDI Matrix Utilizing Online Soft-Landing Ion Mobility, G.F. Verbeck and S. Davila. US patent number 08610058. December 17, 2013.
  • Petroleum Analysis Using Liquid Nitrogen Cold Stage Laser Ablation ICP Mass Spectrometry, G.F. Verbeck and W. Hoffmann. US patent number 08586943, November 19, 2013.