Ron Mittler

Biological Sciences

Dr. Mittler is currently Professor in the Department of Biological Sciences, University of North Texas. From 2003-2010, he served as Associate Professor in the Department of Biochemistry & Molecular Biology, University of Nevada. He obtained a B.A. (Cum Laude) and M.Sc. from the Hebrew University of Jerusalem; and a Ph.D. from Rutgers, The State University of New Jersey. Honors include: The "Yigal Alon" Fellowship for excellent young scientists (1996-99); The "M. Landau" Research Prize for research on PCD in plants (1998); Rector's list of Excellent Teachers at the Hebrew University (1998-9); Jay Philips Foundation Academic Lectureship in Life Sciences (2001); “Cathedra” for excellent young scientists from the Technion (2000-02); Senior Scholar Program, College Distinguished Mentor (2005). CABNR Outstanding Research Award (2007); Thomson Reuters 2014 list of highly cited researchers (2014-5). Lady Davis Fellowship (2016).

Research Interests: 
  • The ROS Wave and Ultrafast Omics Responses to Abiotic Stress. Research from my lab uncovered a new and exciting cell-to-cell communication pathway (The reactive oxygen species - ROS wave) that, together with calcium and electric signals, could provide a working model demonstrating how plant cells transmit long-distance signals via cell-to-cell communication mechanisms.
  • Stress Combination. My lab pioneered the use of omics tools to study abiotic stress combination and opened the way to improving the tolerance of plants to important stresses such as drought and heat that are posing a major threat to agricultural production worldwide.
  • Regulation of Cell Survival and Death Pathways by Fe-S Proteins. We are a key part of a multi-PI collaboration to define the role of NEET proteins in cancer cells. Our studies show that the function of NEET proteins is required for cancer cells to maintain their iron/ROS homeostasis and that targeting the Fe-S clusters of these proteins with new drugs selectively kills cancer cells. We are also studying the cellular pathways that interact with nanoparticles to effectively deliver anticancer drugs.
  • NSF/MCB-BSF. Integrating ROS, redox and cell metabolism across plant and animal cells. (pi). $854,609. 6/30/16-5/1/20.
  • National Science Foundation (IOS) Ultrafast Omics Reveals Key Players in the Response of Plants to Abiotic Stress. (PI). $780,000. 4/1/14-3/30/18.
  • National Science Foundation (IOS) Regulation of Mitochondrial Functions by Iron and Ceramides in C. elegans (Co-PI). $992,056. 5/15/16-5/14/20.

Full List: Google Scholar

Darash-Yahanaa, M., Pozniakb, Y., Luc, M., Sohn, Y-S., Karmi, O., Tamir, S., Bai, F., Song, L., Jennings, P.A., Pikarsky, E., Geiger, T., Onuchic, J.N., Mittler, R. and Nechushtai, R. (2016). Breast cancer tumorigenicity is dependent on high expression levels of NAF-1 and the lability of its Fe-S clusters. Proc Natl Acad Sci U S A. In press.

Danielpur, L., Sohn, Y-S., Karmi, O., Fogel, C., Zinger, A., Abu-Libdeh, A., Israeli, T., Riahi, R., Pappo, O., Birk, R., Zangen, D.H., Mittler, R., Cabantchik, Z.I., Cerasi, E., Nechushtai, R. and Leibowitz, G. (2016). GLP-1-RA corrects mitochondrial labile iron accumulation and improves beta-cell function in type 2 Wolfram syndrome. J. Clinical Endocrinology & Metabolism. Jul 26:jc20162240. [Epub ahead of print].

Suzuki, N., Devireddy, A.R., Inupakutika, M.A., Baxter, A., Miller, G., Song, L., Shulaev, E., Azad, R.K., Shulaev, V. and Mittler, R. (2015). Ultra-fast alterations in mRNA levels uncover multiple players in light stress acclimation in plants. Plant J. 84(4):760-72.

Mittler, R. and Blumwald, E. (2015). The Roles of ROS and ABA in Systemic Acquired Acclimation. Plant Cell. 27(1):64-70.

Gilroy, S., Suzuki, N., Miller, G., Choi, W.G., Toyota, M., Devireddy, A.R. and Mittler, R. (2014). A tidal wave of signals: calcium and ROS at the forefront of rapid systemic signaling. Trends Plant Science 19(10):623-630.

Sohn, Y.S., Tamir, S., Song, L., Michaeli, D., Matouk, I., Conlan, A.R., Harir, Y., Holt, S.H., Shulaev, V., Paddock, M.L., Hochberg, A., Cabanchick, I.Z., Onuchic, J.N., Jennings, P.A., Nechushtai, R. and Mittler, R. (2013), NAF-1 and mitoNEET are central to human breast cancer proliferation by maintaining mitochondrial homeostasis and promoting tumor growth. Proc Natl Acad Sci U S A. 110(36):14676-81.

Suzuki, N., Miller, G., Salazar, C., Mondal, H.A., Shulaev, E., Cortes, D.F., Shuman, J.L., Luo, X., Shah, J., Schlauch, K., Shulaev, V. and Mittler, R. (2013). Temporal-spatial interaction between ROS and ABA controls rapid systemic acclimation in plants. Plant Cell. 25(9):3553-69.

Nechushtai, R., Conlan, A., Song, L., Harir, Y., Yogev, O., Eisenberg-Domovich, Y., Livnah, O., Michaeli, D., Rosen, R., Ma, V., Luo, Y., Zuris, J.A., Shulaev, V., Paddock, M.L., Cabantchik, I., Jennings, P.A. and Mittler, R. (2012). Arabidopsis thaliana ChloroNEET, a Member of the New NEET Family of Human Proteins, is Involved in Development, Senescence and Iron Metabolism. Plant Cell. 24:2139-2154.

Suzuki, N., Sejima, H., Tam, R., Schlauch, K. and Mittler, R. (2011). Identification of the MBF1 heat-response regulon of Arabidopsis thaliana. Plant J. 66(5):844-51.

Mittler, R., Vanderauwera, S., Suzuki, N., Miller, G., Tognetti, V.B., Vandepoele, K., Gollery, G., Shulaev, V. and Van Breusegem, F. (2011). ROS signaling: The new wave? Trends Plant Sci. 16(6):300-9.