Antonella Longo | BioDiscovery Institute
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Antonella Longo

Research Assistant Professor

Antonella Longo, Ph.D. obtained her B.S. in Biology from the University of Tor Vergata in Rome and her Ph.D. in Biophysics from the International School for Advanced Studies in Trieste, Italy. Post-doctoral studies brought her to the University of North Carolina in Chapel Hill and to the NIEHS in the Research Triangle Park. Subsequently, she held a joint faculty position between the Department of Molecular and Structural Biochemistry at NCSU, and the Oak Ridge National Laboratory. In 2012, she joined the Department of Biological Sciences at UNT as research assistant professor.

She has been a member of the ORNL Neutron Scattering Science Review Committee since 2011. She also served in the SHUG (SNS and HFIR User Group) executive committee (2010-2014).

Dr. Longo has successfully used x-ray crystallography to determine the structure of several proteins including human transcription factors in complex with their target DNA and a yeast intron-encoded maturase. Since joining UNT, she has expanded her interests to plant enzymes involved in the flavonoid metabolic pathway as well as to nitrate transporters in plants, algae, and diatoms.


  • Structural and functional studies of flavonoid biosynthetic enzymes.
  • Role of chirality in flavonoids biosynthesis.
  • Structural evolution of nitrate transporters in plants, algae, and diatoms.


1. Longo, A.*, Miles, N.W., Dickstein, R. (2018). Genome mining of plant NPFs reveals varying conservation of signature motifs associated with the mechanism of transport. Frontiers in Plant Biology, 9, 1668. doi: 10.3389/fpls.2018.01668. (* corresponding author)

2. Longo, A., Guanga, G.P., Rose, R.B. (2008). Crystal structure of E47-NeuroD1/Beta2 bHLH domain-DNA complex: heterodimer selectivity and DNA recognition. Biochemistry 47: 218-29.

3. Longo, A, Guanga, G.P., Rose, R.B. (2007) Structural basis for induced fit mechanisms in DNA recognition by the Pdx1 homeodomain. Biochemistry 46: 2948-57.

4. Longo, A., Leonard, C.W., Bassi, G.S., Berndt, D., Krahn, J.M., Hall, T.M., Weeks, K.M., (2005) Evolution from DNA to RNA recognition by the bI3 LAGLIDADG maturase. Nat. Struct. Mol. Biol., 12: 779-87.

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