Clement Chan | BioDiscovery Institute

Clement Chan

Assistant Professor

Clement Chan participated in academic research since he was an undergraduate at the University of Wisconsin-Madison. After accomplished his B.S. degree in Chemistry and Biochemistry, he joined a Ph.D. program in Biological Chemistry at Massachusetts Institute of Technology and conducted his thesis research in the laboratory of Peter C. Dedon, M.D., Ph.D. at the Department of Biological Engineering. As a graduate student, Dr. Chan used a quantitative systems approach to study biological roles of tRNA modifications in cellular response to different types of stress. With Saccharomyces cerevisiae as a model organism, he developed a mass spectrometric platform to quantify tRNA modifications, which led to the discovery of specific changes in the quantitative pattern of tRNA modification spectrum in response to different types of stress.

During his postdoctoral training in the laboratory of James J. Collins, Ph.D. at Harvard University and Massachusetts Institute of Technology, Dr. Chan continued to conduct systems biology research while using transcriptomics and proteomics analyses to understand the bacterial response to antibiotics. Additionally, he also developed his research in synthetic biology, including using protein engineering methods to construct a series of biosensors for the detection of different small molecules and harnessing these biosensors to build a programmable "Passcode" genetic circuit to control cellular behaviors in response to multiple environmental signals. After he became a faculty, he continues to use these systems and synthetic biology approaches to understand and construct biological systems.